Several important peptide hormones are secreted from the pituitary gland. The anterior pituitary secretes three hormones: prolactin , which acts on the mammary gland ; adrenocorticotropic hormone (ACTH), which acts on the adrenal cortex to regulate the secretion of glucocorticoids ; and growth hormone , which acts on bone , muscle , and the liver . The posterior pituitary gland secretes antidiuretic hormone , also called vasopressin, and oxytocin . Peptide hormones are produced by many different organs and tissues, however, including the heart ( atrial-natriuretic peptide (ANP) or atrial natriuretic factor (ANF)) and pancreas ( glucagon , insulin and somatostatin ), the gastrointestinal tract ( cholecystokinin , gastrin ), and adipose tissue stores ( leptin ).  
In addition, high levels of corticotrophin-releasing hormone may also make certain inflammatory problems worse, including rheumatoid arthritis, psoriasis , ulcerative colitis and Crohn's disease. Initially this might seem unexpected because raised levels of corticotrophin-releasing hormone in the brain can lead to increased glucocorticoids production, and glucocorticoids have an anti-inflammatory effect. However, research has revealed that when high levels of corticotrophin-releasing hormone occur in tissues outside the brain, they can actually have a powerful inflammatory action. Increased corticotrophin-releasing hormone levels within the joints, skin or gut can therefore make these inflammatory conditions worse or even play a role in their development.