More recently, androgen receptors have been shown to have a second mode of action. As has been also found for other steroid hormone receptors such as estrogen receptors , androgen receptors can have actions that are independent of their interactions with DNA.   Androgen receptors interact with certain signal transduction proteins in the cytoplasm. Androgen binding to cytoplasmic androgen receptors can cause rapid changes in cell function independent of changes in gene transcription, such as changes in ion transport . Regulation of signal transduction pathways by cytoplasmic androgen receptors can indirectly lead to changes in gene transcription, for example, by leading to phosphorylation of other transcription factors.
Synthetic tetrahydrocannabinol (THC) is prescribed under the INN dronabinol or the brand name Marinol , to treat vomiting and for enhancement of appetite , mainly in people AIDS as well as for refractory nausea and vomiting in people undergoing chemotherapy .  THC is also an active ingredient in nabiximols , a specific extract of Cannabis that was approved as a botanical drug in the United Kingdom in 2010 as a mouth spray for people with multiple sclerosis to alleviate neuropathic pain , spasticity , overactive bladder , and other symptoms.