We watch as a gloved medical service provider wipes his arm in a most delicate manner. Why? Isn’t it obvious? She’s cleaning the gaping hole in his arm as the Synthol has caused a reaction, a burning sensation unlike anything experienced, and a deadly infection. The fluid inside of his arms is expanding and wants to follow the path of least resistance but there isn’t any. With no other option, the arm bursts open like a ruptured tire. The debris of flesh surrounds the huge hole and fluids are gushing to the external. Intense pain rages and the young Brazilian will soon go into shock.
Transdermal patches (adhesive patches placed on the skin) may also be used to deliver a steady dose through the skin and into the bloodstream. Testosterone-containing creams and gels that are applied daily to the skin are also available, but absorption is inefficient (roughly 10%, varying between individuals) and these treatments tend to be more expensive. Individuals who are especially physically active and/or bathe often may not be good candidates, since the medication can be washed off and may take up to six hours to be fully absorbed. There is also the risk that an intimate partner or child may come in contact with the application site and inadvertently dose himself or herself; children and women are highly sensitive to testosterone and can suffer unintended masculinization and health effects, even from small doses. Injection is the most common method used by individuals administering AAS for non-medical purposes. 
After the double-murder suicide, former wrestler Christopher Nowinski contacted Benoit's father, suggesting that years of trauma to his son's brain may have led to his actions. Tests were conducted on Benoit's brain by Julian Bailes, the head of neurosurgery at West Virginia University, and results showed that "Benoit's brain was so severely damaged it resembled the brain of an 85-year-old Alzheimer's patient." He was reported to have had an advanced form of dementia, similar to the brains of four retired NFL players who had suffered multiple concussions, sank into depression, and harmed themselves or others. Bailes and his colleagues concluded that repeated concussions can lead to dementia, which can contribute to severe behavioral problems.