Corticosteroids have been used as drug treatment for some time. Lewis Sarett of Merck & Co. was the first to synthesize cortisone, using a complicated 36-step process that started with deoxycholic acid, which was extracted from ox bile .  The low efficiency of converting deoxycholic acid into cortisone led to a cost of US $200 per gram. Russell Marker , at Syntex , discovered a much cheaper and more convenient starting material, diosgenin from wild Mexican yams . His conversion of diosgenin into progesterone by a four-step process now known as Marker degradation was an important step in mass production of all steroidal hormones, including cortisone and chemicals used in hormonal contraception .  In 1952, . Peterson and . Murray of Upjohn developed a process that used Rhizopus mold to oxidize progesterone into a compound that was readily converted to cortisone.  The ability to cheaply synthesize large quantities of cortisone from the diosgenin in yams resulted in a rapid drop in price to US $6 per gram, falling to $ per gram by 1980. Percy Julian's research also aided progress in the field.  The exact nature of cortisone's anti-inflammatory action remained a mystery for years after, however, until the leukocyte adhesion cascade and the role of phospholipase A2 in the production of prostaglandins and leukotrienes was fully understood in the early 1980s.
All anabolic steroid use not prescribed by a licensed physician, is more properly defined as “ steroid abuse ”.ÂÂÂ The reason for this is simple, “ Steroids are very powerful hormones that can be extremely dangerous!”ÂÂÂ They can cause a variety of health problems some of which can have lasting ramifications.ÂÂÂ Although the twenty-three steroid related dangers listed below are not exhaustive, they certainly illustrate the risks and potentially harmful effects abusers face.
For the past 17 months I have participated in the no steroid creme re TSW. Wow, it has been a journey, but I do believe you are correct with all you information. I am still NOT where I would like to be,but probably 60 percent better than with steroid cremes. I live in Switzerland and have have done uva and uvb light therapy as well, and visited Avene thermal spa. I also spent a fair amount of time on the Atlantic ocean trying to heal. So, as I see you have commented on Eucrisa tm.. (criaborole). I would like to comment, that I experienced a severe reaction to the creme after 8 days of use… ( the company Pfizer has my photos etc )