Prednicare steroid

Dosing should be individualized based on disease and patient response:

Initial dose: 5 to 60 mg orally per day; may be give once a day or in divided doses
Maintenance dose: Adjust or maintain initial dose until a satisfactory response is obtained; then, gradually in small decrements at appropriate intervals decrease to the lowest dose that maintains an adequate clinical response

Comments:
-Exogenous corticosteroids suppress adrenocorticoid activity the least when given at the time of maximal activity; consider time of maximal adrenal cortex activity (2 AM to 8 AM) when dosing.
-Alternate day therapy may be considered in patients requiring long-term treatment; it may be necessary to return to a full suppressive daily dose in the event of acute flare-ups.

Uses: As an anti-inflammatory or immunosuppressive agent when corticosteroid therapy is appropriate, such as treatment of certain allergic states; nervous system, neoplastic, or renal conditions; endocrine, rheumatologic, or hematologic disorders; collagen, dermatologic, ophthalmic, respiratory, or gastrointestinal diseases; specific infectious diseases or conditions related to organ transplantation.

Adverse reactions (frequency and seriousness):
Anti-inflammatory steroids, such as prednisolone, are known to exert a wide range of side-effects. Whilst single high doses are generally well tolerated, they may induce severe side-effects in long-term use and when esters possessing a long duration of action are administered. Dosage in medium to long term should therefore generally be kept to the minimum necessary to control symptoms. Steroids themselves, during treatment, may cause Cushingoid symptoms involving significant alteration of fat, carbohydrate, protein and mineral metabolism, ., redistribution of body fat, muscle weakness and osteoporosis may result.
During therapy, effective doses suppress the Hypothalamo-Pituitreal-Adrenal axis. Following cessation of treatment, symptoms of adrenal insufficiency extending to adrenocorticol atrophy can arise and this may render the animal unable to deal adequately with stressful situations. Consideration should therefore be given to means of minimising problems of adrenal insufficiency following the withdrawal of treatment, ., dosing on alternate days, dosing to coincide with the endogenous cortisol peak (., in the morning with regard to dogs and in the evening with regard to cats) and a gradual reduction in dosage (for further discussion see standard texts).
Systemically acting corticosteroids may cause polyuria, polydipsia and polyphagia, particularly during the early stages of therapy. Some corticosteroids may cause sodium and water retention and hypokalaemia in long term use. Systemic corticosteroids have caused deposition of calcium in the skin (calcinosis cutis).
Corticosteroids are not recommended for use in pregnant animals. Administration in early pregnancy is known to have caused foetal abnormalities in laboratory animals. Administration in late pregnancy may cause early parturition or abortion.
Corticosteroids may delay wound healing and the immunosuppressant actions may weaken resistance to or exacerbate existing infections. In the presence of bacterial infection, anti-bacterial drug cover is usually required when steroids are used. In the presence of viral infections, steroids may worsen or hasten the progress of the disease.
Gastrointestinal ulceration has been reported in animals treated with corticosteroids and . ulceration may be exacerbated by steroids in patients given non-steroidal anti-inflammatory drugs and in corticosteroid treated animals with spinal cord trauma.
Steroids may cause enlargement of the liver (hepatomegaly) with increased serum hepatic enzymes.

The first isolation and structure identifications of prednisone and prednisolone were done in 1950 by Arthur Nobile . [22] [23] [24] The first commercially feasible synthesis of prednisone was carried out in 1955 in the laboratories of Schering Corporation, which later became Schering-Plough Corporation , by Arthur Nobile and coworkers. [25] They discovered that cortisone could be microbiologically oxidized to prednisone by the bacterium Corynebacterium simplex. The same process was used to prepare prednisolone from hydrocortisone . [26]

My dog (2yrs) had diarrhea and was vomiting. I took him to his vet and the dog injected 2 meds and prescribed Metronidazole 250mg to be taken daily w/food (full stomach). The vet said to give him babyfood till he's better. Once my dog started eating the babyfood, I gave him his 1st pill. However, I haven't given him the 2nd dosage because my dog won't eat or drink water. He has a lil diarrhea and is going frequently although it's not much what he excretes. My question: can & should I cont to give Metronidazole on an empty stomache? He's lost his appetite and I worry of giving the med cause of this.

Prednicare steroid

prednicare steroid

My dog (2yrs) had diarrhea and was vomiting. I took him to his vet and the dog injected 2 meds and prescribed Metronidazole 250mg to be taken daily w/food (full stomach). The vet said to give him babyfood till he's better. Once my dog started eating the babyfood, I gave him his 1st pill. However, I haven't given him the 2nd dosage because my dog won't eat or drink water. He has a lil diarrhea and is going frequently although it's not much what he excretes. My question: can & should I cont to give Metronidazole on an empty stomache? He's lost his appetite and I worry of giving the med cause of this.

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