Ovarian steroidogenesis pdf

Modifications in the adrenergic activity of the celiac ganglion results in an altered capacity of the ovary of pregnant rats to produce progesterone, suggesting that the celiac ganglion-superior ovarian nerve-ovarian axis provides a direct link between the autonomic nervous system and the physiology of pregnancy. [1] It has also been shown that modifications in the cholinergic input at the celiac ganglion also led, via the superior ovarian nerve, to modifications in ovarian steroidogenesis . [1] [2] [3] Most of the fibers of the superior ovarian nerve come from the postganglionic sympathetic neurons of the celiac ganglion.

Like the previous theca cells, the theca lutein cells lack the aromatase enzyme that is necessary to produce estrogen, so they can only perform steroidogenesis until formation of androgens . The granulosa lutein cells do have aromatase, and use it to produce estrogens, using the androgens previously synthesized by the theca lutein cells, as the granulosa lutein cells in themselves do not have the 17α-hydroxylase or 17,20 lyase to produce androgens. [4] Once the corpus luteum regresses the remnant is known as corpus albicans . [11]

An overnight dexamethasone suppression test should be performed in women with physical features of cortisol excess, such as hypertension, central obesity, facial plethora, easy bruising, striae, proximal muscle weakness and/or increased cervicodorsal-supra-clavicular fat. For this test, 1 mg of dexamethasone is administered orally at 11 ., and serum cortisol measurements are taken at 8 . the following morning. Serum cortisol levels below 5 μg per dL (140 nmol per L) make the diagnosis of Cushing's syndrome unlikely but are routinely present in women with polycystic ovary syndrome.

Ovarian steroidogenesis pdf

ovarian steroidogenesis pdf


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