Health problems. Lots of things that can go wrong here but I wont bother to go into too much detail because you have heard it all before. These problems are very dosage dependent and drug dependent. Enlargement of the heart is probably the biggest problem. Although enlarging your heart sounds like a good thing, its very, very bad and is what leads to heart attacks in young bodybuilders. Damaging your kidneys and liver is another relatively common problem as the body works overtime to filter out stuff that it doesnt want. Then there is the problem with natural testosterone production being shut down.
Acromegaly patients, who suffer from natural growth hormone levels of up to 100 times higher than normal, have lower stamina towards physical activity than people with regular levels.  When the patients are treated and their growth hormone levels decrease, their stamina improves.  This knowledge is part of the evidence behind the new belief that athletes who use supplemental HGH to raise their levels far above average could actually decrease their exercise tolerance, and thus hurt their athletic performance.  Further backing was provided in a study done by the Danish Institute of Sports Medicine. They found cyclists of good health and endurance “were unable to complete accustomed cycling tasks after administration of exogenous hGH” and concluded that HGH can inhibit recuperation from exercise.  Participants have also been found to have lower stamina after HGH treatment along with higher rates of fatigue. 
In 1997, Phillips was eager to expand his empire beyond the bodybuilding industry. MM2K changed from targeting the hardcore bodybuilder to the more mainstream exercise participant, and the July 1997 issue saw the magazine redubbed simply as Muscle Media .  While Muscle Media 2000 had a distribution of 500,000 copies per issue at its peak,  the change in direction alienated many traditional readers, and sales numbers reportedly declined sharply afterwards.   Publication finally ceased in 2004 after the EAS company was sold a second time.