Myokem Alphadex is an elite hormone modulator that was designed to manipulate estrogen from two pathways, which are aromatase inhibitors (AI’s) and selective estrogen receptor modulators (SERM’s). The three unique compounds that this formula uses are brassaiopsis glomerulata extract, garcinia mangostana extract, and acacetin. Brassaiopsis glomerulata extract has received a lot of attention recently due to its potent aromatase inhibition. Garcinia mangostana extract is also a potent aromatase inhibitor. Acacetin has been shown to reduce aromatase activity by up to 63% while having no estrogenic activity.
Low levels of serotonin , a neurotransmitter in the brain, have been linked to depression . High levels of estrogen, as in first-generation COCPs, and progestin, as in some progestin-only contraceptives, have been shown to lower the brain serotonin levels by increasing the concentration of a brain enzyme that reduces serotonin. This observation, along with some small research studies  have inspired speculation that the pill causes depression. In 2016, a large Danish study of one million women showed that use of COCPs, especially among adolescents, was associated with a statistically significantly increased risk of subsequent depression, although the sizes of the effects are small (for example, % of the women who took any form of oral birth control were prescribed anti-depressants for the first time, compared to % of women in the control group).