There are several reasons for the development of antibiotic-resistant bacteria. One of the most important is antibiotic overuse. This includes the common practice of prescribing antibiotics for the common cold or flu . Even though antibiotics do not affect viruses , many people expect to get a prescription for antibiotics when they visit their doctor. Although the common cold is uncomfortable, antibiotics do not cure it, nor change its course. Each person can help reduce the development of resistant bacteria by not asking for antibiotics for a common cold or flu.
In a multigenerational developmental study in pregnant rats given oral gavage doses of , 1, 3 g/kg/day ethyl-EPA from gestation day 7-17, an increased incidence of absent optic nerves and unilateral testes atrophy were observed at ≥ g/kg/day at human systemic exposure following an oral dose of 4 g/day based on body surface area comparisons across species. Additional variations consisting of early incisor eruption and increased percent cervical ribs were observed at the same exposures. Pups from high dose treated dams exhibited decreased copulation rates, delayed estrus, decreased implantations and decreased surviving fetuses (F2) suggesting multigenerational effects of ethyl-EPA at 7 times human systemic exposure following 4 g/day dose based on body surface area comparisons across species.
A variety of infectious agents may be transmitted by transfusion. Definitive evidence of transmission by transfusion requires demonstration of seroconversion or new infection in the recipient and isolation of an agent with genomic identity from both the recipient and the implicated donor. Strong presumptive evidence of transfusion transmission includes recipient seroconversion within an appropriate interval after transfusion, the recognition of appropriate infectious markers in an implicated donor on follow-up investigation, or both. Transfusion transmitted disease should be reported to the Australian Red Cross Blood Service.